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All of the B vitamins are needed for a healthy, functioning nervous system and several are needed to synthesize serotonin (16).Here are a few that are integrally connected to serotonin production.

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.

For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.

Vitamin B6 (pyridoxine): Vitamin B6 must be present to facilitate conversion of either 5-HTP or tryptophan into serotonin (17, 18).

Often 5-HTP or tryptophan supplements also contain B6 for this reason.




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